Gene Express, Inc. has licensed certain patented technology for an exclusive worldwide license to use the technology for commercial purposes from the University of Rochester and the Medical University of Ohio. The U.S. and foreign patents licensed by Gene Express are based on Dr. Willey's work at the University of Rochester and at the Medical University of Ohio. Gene Express has licensed the technology covered by Patent Nos. 5,643,765 and 5,639,606 from the University of Rochester and Patent No. 5,876,978 from Medical University of Ohio. The Company's multi-gene expression technology recently received 11 international patents from European Union, Japan and Russia with additional patents expected.

Additional 9 patents are pending covering molecular diagnostic products and ITAI - Interactive Transcript Abundance Indices in several countries.

The three foundation patents covering StaRT-PCR Technology and the use of SMIS - Standardized Mixture of Internal Standards are listed below:

United States Patent # 5,639,606
Inventor: Willey, James C. June 17, 1997

Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction


United States Patent # 5,643,765
Inventor: Willey, James C. July 1, 1997

Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction


United States Patent # 5,876,978
Inventor, Willey, et al. March 2, 1999

Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction